ODCs

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1 OMIM reference -
1 associated gene
36 signs/symptoms

COMMON GENES: 1
COMMON SIGNS: 12

1 OMIM reference -
1 associated gene
15 signs/symptoms

Familial partial lipodystrophy, Dunnigan type

Familial partial lipodystrophy, KÃ¶bberling type

LMNA

Citations in the biomedical literature:

Familial partial lipodystrophy, Dunnigan type		Familial partial lipodystrophy, KÃ¶bberling type
	Synonym(s): - Dunnigan syndrome - FPLD2 - Familial partial lipodystrophy type 2		Synonym(s): - FPLD1 - Familial partial lipodystrophy type 1

	Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Endocrine, nutritional and metabolic diseases -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: unknown Average age onset: childhood Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: adolescence / young Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references


COMMON SIGNS	- Abnormal fat distribution / lipodystrophy - Abnormal / polycystic ovaries - Acanthosis nigricans - Angor pectoris / myocardial infarction - Autosomal dominant inheritance - Diabetes mellitus - Hepatomegaly / liver enlargement (excluding storage disease) - Insulin resistance - Lipoatrophy - Liver / hepatic steatosis - Pancreatitis - Xanthomas / lipomas

Familial partial lipodystrophy, Dunnigan type		Familial partial lipodystrophy, KÃ¶bberling type
	Very frequent - Hyperlipidemia / hypercholesterolemia / hypertriglyceridemia - Muscle hypertrophy - Round face - Skin hypoplasia / aplasia / atrophy Frequent - Anomalies of skin, subcutaneous tissue and mucosae - Arterial atheroma / precocious atherosclerosis / arteriosclerosis - Nails anomalies - Precocious menopause / secondary amenorrhea - Premature eruption of teeth / natal teeth - Thin skin Occasional - Abnormal muscle biopsy / muscle enzymes / CPK / LDH / aldolase / creatin phosphokinase - Anomalies of complement - Cardiomyopathy / hypertrophic / dilated - Cellulitis / panniculitis / pseudocellulitis / inflammation of subcutaneous tissue - Cranial nerves palsy - Heart / cardiac failure - Hirsutism / hypertrichosis / Increased body hair - Maternal hypertension / eclampsia / preeclampsia / gravidic toxemia - Metrorrhagia / menorrhagia / hemorrhagic cycles / hyper / poly / spanio / dysmenorrhea - Myalgia / muscular pain - Myopathy - Renal glomerular defect / glomerulopathy - Splenomegaly - Storage liver disease		Very frequent - Chronic arterial hypertension - Hyperinsulinism / hyperinsulinemia - Insulin-dependent / type 1 diabetes